Infections in severe alcoholic hepatitis

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Infections in severe alcoholic hepatitis

Severe alcoholic hepatitis (sAH), defined by a modified discriminant function ≥32, is the most severe form of alcohol-induced liver disease and is associated with a 1-month mortality rate of around 30%. Corticosteroid treatment remains the only therapeutic option that improves short-term survival. Infectious complications, occurring in approximately 50% of patients, are the main causes of death...

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Pentoxifylline and prednisolone in severe alcoholic hepatitis.

published under the permission of the editor ofWorld J Gastroenterol All authors disclosed that there is no conflict of interest with authors or institutions referred in the manuscript.

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Early liver transplantation for severe alcoholic hepatitis.

BACKGROUND A 6-month abstinence from alcohol is usually required before patients with severe alcoholic hepatitis are considered for liver transplantation. Patients whose hepatitis is not responding to medical therapy have a 6-month survival rate of approximately 30%. Since most alcoholic hepatitis deaths occur within 2 months, early liver transplantation is attractive but controversial. METHO...

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Invasive aspergillosis in patients with severe alcoholic hepatitis.

BACKGROUND & AIMS Severe alcoholic hepatitis (AH) has a poor short-term prognosis. Although infections are frequent complications of AH, the incidence of invasive aspergillosis (IA) and its impact on outcome remain unknown. METHODS We prospectively followed 94 biopsy-proven severe AH episodes for 3 months. We retrospectively reviewed our diagnosis of IA based on EORTC/MSG and AspICU criteria,...

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Pentoxifylline in severe alcoholic hepatitis: a prospective, randomised trial.

BACKGROUND Role of corticosteroids in treatment of severe alcoholic hepatitis (SAH) is controversial. Pentoxifylline (PTX), an inhibitor of TNF, has also been shown to decrease short term mortality in SAH. Aim of this study was to evaluate the effect of PTX on short term mortality, renal and hepatic functions in patients with SAH. METHODS Fifty patients with SAH {Maddrey's Discriminant Functi...

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ژورنال

عنوان ژورنال: Annals of Gastroenterology

سال: 2016

ISSN: 1792-7463

DOI: 10.20524/aog.2016.0101